Quantitative Aspects of Bilirubin Metabolism for Hematologists
ثبت نشده
چکیده
Techniques now available for the study of plasma disappearance kinetics of isotopically labeled unconjugated bilirubin have led to new insights into the factors that determine the plasma unconjugated bilirubin concentration (BR). This variable can be shown to depend in turn on five other parameters: the total circulating red cell volume (TRVC), the mean corpuscular hemoglobin concentration (MCHC). the mean red cell lifespan (RBCLS). plasma volume (PV), and the hepatic extraction coefficient for unconjugated bilirubin (k.). Of these, three clearly relect varying aspects of erythrokinetics and red cell physiology, while only one is reflective of liver function. It is not surprising. therefore. that knowledgable interpretations of
منابع مشابه
Quantitative aspects of bilirubin metabolism for hematologists.
Techniques now available for the study of plasma disappearance kinetics of isotopically labeled unconjugated bilirubin have led to new insights into the factors that determine the plasma unconjugated bilirubin concentration (BR). This variable can be shown to depend in turn on five other parameters: the total circulating red cell volume (TRVC), the mean corpuscular hemoglobin concentration (MCH...
متن کاملQuantitative assessment of the multiple processes responsible for bilirubin homeostasis in health and disease
Serum bilirubin measurements are commonly obtained for the evaluation of ill patients and to screen for liver disease in routine physical exams. An enormous research effort has identified the multiple mechanisms involved in the production and metabolism of conjugated (CB) and unconjugated bilirubin (UB). While the qualitative effects of these mechanisms are well understood, their expected quant...
متن کاملNew Aspects of Bilirubin Effects in Health and Disease: a Review
Bilirubin belongs to a phylogenetically old superfamily of tetrapyrrolic compounds. Although for decades bilirubin was believed to be only a waste product of the heme catabolic pathway and a potentially toxic compound; recent data has convincingly demonstrated that mildly elevated serum bilirubin levels are strongly associated with a lower prevalence of oxidative stress-mediated diseases, such ...
متن کاملQuantitative Assessment of Analytical Phase Quality of Clinical Biochemistry Parameters Using Sigma Metrics
Background and Aims: Six sigma is the latest version of total quality management. It is quantitative goal for process performance. With increasing demands for improved accuracy and reliability of the results, Six Sigma is gaining increased visibility in the clinical laboratory process outcomes. The aim of study was to evaluate the quality of analytical phase performance in a clinical biochemist...
متن کامل[metabolism of Hemoglobin and Bile Pigments].
This presentation is designed to review the catabolic aspects of the metabolism of hemoglobin. Emphasis will be placed pri marily on observations during the past few years which have expanded knowledge in this field considerably and have elucidated further the classical concepts of the degra dation of hemoglobin. Some details, how ever, still remain uncertain. Review arti cles1, 6’ 8i n ’ 2...
متن کامل